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THERAPEUTICAL APPLICATIONS
List of diseases treatable with cord blood (CB) and bone marrow stem cell transplants
Disease CB
Autologous
CB
Allogeneic
Autologous
Bone
Marrow
Allogeneic
Bone
Marrow
Acute Leukemias
Acute Lymphocytic Leukemia YES (-) YES YES (-) YES
Acute Myelogenous Leukemia YES YES YES YES
Chronic Leukemias
Chronic Lymphocytic Leukemia YES YES YES (-) YES
Chronic Myelogenous Leukemia YES YES YES (-) YES
Juvenile Myelomonocytic Leukemia YES YES YES (-) YES
Myelodysplastic Syndromes
Chronic Myelomonocytic Leukemia YES YES NO YES
Refractory anemia YES YES YES (-) YES
Stem Cell Disorders
Severe Aplastic Anemia YES YES NO YES
Congenital NO YES NO YES
Fanconi Anemia NO YES NO YES
Lymphoproliferative Disorders
Refractory Hodgkin's Disease YES YES YES ±
Non-Hodgkin's Lymphoma YES YES YES ±
Plasma Cell Disorders
Multiple Myeloma YES YES YES (-) ±
Other Malignancies
Breast Cancer (YES) (YES) (YES) EXP
Ovarian Cancer (YES) (YES) (YES) EXP
Brain Tumour YES (YES) YES NO
Ewing Sarcoma YES (YES) YES EXP
Solid Tumors (neuroblastoma or retinoblastoma) YES YES YES ±
Renal Cell Carcinoma (YES) (YES) (YES) YES / EXP
Testicular Cancer YES YES YES EXP
Autoimmune Diseases
Evans Syndrome YES YES EXP NO
Multiple Sclerosis YES YES YES (-) EXP
Rheumatoid Arthritis YES YES YES (-) EXP
Metabolic Disorders
Hunter's Syndrome NO YES NO YES
Hurler's Syndrome NO YES NO YES
Krabbe Disease NO YES NO YES
Maroteaux-Lamy Syndrome NO YES NO YES
Histiocytic Disorders
Langerhans' Cell Histiocytosis NO YES NO YES
Hereditary Hemoglobinopathies
Blackfan-Diamond Anemia NO YES NO YES
Sickle Cell Disease NO YES NO YES
Inherited Immune System Disorders
Kostmann Syndrome NO YES NO YES
Omenn's Syndrome NO YES NO YES
Severe Combined Immunodeficiency NO YES NO YES
Adenosine Deaminase Deficiency NO YES NO YES
Wiskott-Aldrich Syndrome NO YES NO YES
X-Linked Lymphoproliferative Disorder NO YES NO YES
Other Inherited Disorders
Lesch-Nyhan Syndrome NO YES NO YES
Osteopetrosis NO YES NO YES
Tay Sachs Disease NO YES NO YES
Amegakaryocytic thrombocytopenia NO YES NO YES
Potential Future Stem Cell Applications
Alzheimer's Disease YES NO YES NO
Diabetes YES NO YES NO
Cardiovascular Disease YES NO YES NO
Liver Disease YES NO YES NO
Muscular Dystrophy YES NO YES NO
Parkinson's Disease YES NO YES NO
Spinal Cord Injury YES NO YES NO
Stroke YES NO YES NO
Idiopathic Aplastic Anemia YES YES YES YES
Legend:
YES With CB, transplantation is feasible and total recovery is expected
With bone marrow, standard transplantation is feasible and partial recovery is expected
YES (-) Transplantation is feasible, but total recovery is not expected, only an increase in survival
(YES) Once diagnosed, transplantation is feasible, however currently it is only performed as an experimental procedure.
± In certain cases, transplantation is feasible and total recovery is expected, but the intervention is not used routinely due to the high risks it entails
EXP Method in experimental phase
 
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