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Therapeutical Applications
THERAPEUTICAL APPLICATIONS
List of diseases treatable with cord blood (CB) and bone marrow stem cell transplants
Disease
CB
Autologous
CB
Allogeneic
Autologous
Bone
Marrow
Allogeneic
Bone
Marrow
Acute Leukemias
Acute Lymphocytic Leukemia
YES (-)
YES
YES (-)
YES
Acute Myelogenous Leukemia
YES
YES
YES
YES
Chronic Leukemias
Chronic Lymphocytic Leukemia
YES
YES
YES (-)
YES
Chronic Myelogenous Leukemia
YES
YES
YES (-)
YES
Juvenile Myelomonocytic Leukemia
YES
YES
YES (-)
YES
Myelodysplastic Syndromes
Chronic Myelomonocytic Leukemia
YES
YES
NO
YES
Refractory anemia
YES
YES
YES (-)
YES
Stem Cell Disorders
Severe Aplastic Anemia
YES
YES
NO
YES
Congenital
NO
YES
NO
YES
Fanconi Anemia
NO
YES
NO
YES
Lymphoproliferative Disorders
Refractory Hodgkin's Disease
YES
YES
YES
±
Non-Hodgkin's Lymphoma
YES
YES
YES
±
Plasma Cell Disorders
Multiple Myeloma
YES
YES
YES (-)
±
Other Malignancies
Breast Cancer
(YES)
(YES)
(YES)
EXP
Ovarian Cancer
(YES)
(YES)
(YES)
EXP
Brain Tumour
YES
(YES)
YES
NO
Ewing Sarcoma
YES
(YES)
YES
EXP
Solid Tumors (neuroblastoma or retinoblastoma)
YES
YES
YES
±
Renal Cell Carcinoma
(YES)
(YES)
(YES)
YES / EXP
Testicular Cancer
YES
YES
YES
EXP
Autoimmune Diseases
Evans Syndrome
YES
YES
EXP
NO
Multiple Sclerosis
YES
YES
YES (-)
EXP
Rheumatoid Arthritis
YES
YES
YES (-)
EXP
Metabolic Disorders
Hunter's Syndrome
NO
YES
NO
YES
Hurler's Syndrome
NO
YES
NO
YES
Krabbe Disease
NO
YES
NO
YES
Maroteaux-Lamy Syndrome
NO
YES
NO
YES
Histiocytic Disorders
Langerhans' Cell Histiocytosis
NO
YES
NO
YES
Hereditary Hemoglobinopathies
Blackfan-Diamond Anemia
NO
YES
NO
YES
Sickle Cell Disease
NO
YES
NO
YES
Inherited Immune System Disorders
Kostmann Syndrome
NO
YES
NO
YES
Omenn's Syndrome
NO
YES
NO
YES
Severe Combined Immunodeficiency
NO
YES
NO
YES
Adenosine Deaminase Deficiency
NO
YES
NO
YES
Wiskott-Aldrich Syndrome
NO
YES
NO
YES
X-Linked Lymphoproliferative Disorder
NO
YES
NO
YES
Other Inherited Disorders
Lesch-Nyhan Syndrome
NO
YES
NO
YES
Osteopetrosis
NO
YES
NO
YES
Tay Sachs Disease
NO
YES
NO
YES
Amegakaryocytic thrombocytopenia
NO
YES
NO
YES
Potential Future Stem Cell Applications
Alzheimer's Disease
YES
NO
YES
NO
Diabetes
YES
NO
YES
NO
Cardiovascular Disease
YES
NO
YES
NO
Liver Disease
YES
NO
YES
NO
Muscular Dystrophy
YES
NO
YES
NO
Parkinson's Disease
YES
NO
YES
NO
Spinal Cord Injury
YES
NO
YES
NO
Stroke
YES
NO
YES
NO
Idiopathic Aplastic Anemia
YES
YES
YES
YES
Source:
www.cordbloodcenter.com
Legend:
YES
With CB, transplantation is feasible and total recovery is expected
With bone marrow, standard transplantation is feasible and partial recovery is expected
YES (-)
Transplantation is feasible, but total recovery is not expected, only an increase in survival
(YES)
Once diagnosed, transplantation is feasible, however currently it is only performed as an experimental procedure.
±
In certain cases, transplantation is feasible and total recovery is expected, but the intervention is not used routinely due to the high risks it entails
EXP
Method in experimental phase
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